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The 2nd pain stage is due to an inflammatory response, even though the primary response is acute personal injury to the nerve fibers. Conolidine injection was located to suppress equally the phase 1 and a pair of pain response (sixty). This means conolidine efficiently suppresses both of those chemically or inflammatory pain of each an acute and pe
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The activation of CB1 and CB2 inhibits the development of intracellular cAMP, therefore bringing about an amazing reduction in the excitatory outcome within the neurons [88,89]. In addition, the activation of CB2 can further prevent the mast cell degranulation and the discharge of professional-inflammatory mediators, earning the reduction in pain f